Long-term outcome after the Ross procedure in 173 adults with up to 25 years of follow-up (2024)

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Lucas Van Hoof

Department of Cardiac Surgery, UZ Leuven

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Herestraat 49

, 3000 Leuven,

Belgium

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Bert Rooyackers

Department of Cardiac Surgery, UZ Leuven

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Herestraat 49

, 3000 Leuven,

Belgium

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Art Schuermans

Department of Cardiac Surgery, UZ Leuven

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Herestraat 49

, 3000 Leuven,

Belgium

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Jolien Duponselle

Department of Cardiac Surgery, UZ Leuven

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Herestraat 49

, 3000 Leuven,

Belgium

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Alexander Van De Bruaene

Department of Cardiovascular Diseases, UZ Leuven

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Herestraat 49

, 3000 Leuven,

Belgium

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Pieter De Meester

Department of Cardiovascular Diseases, UZ Leuven

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Herestraat 49

, 3000 Leuven,

Belgium

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Bart Meuris

Department of Cardiac Surgery, UZ Leuven

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Herestraat 49

, 3000 Leuven,

Belgium

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Werner Budts

Department of Cardiovascular Diseases, UZ Leuven

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Herestraat 49

, 3000 Leuven,

Belgium

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Marc Gewillig

Department of Pediatric Cardiology, UZ Leuven

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Herestraat 49

, 3000 Leuven,

Belgium

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Willem Flameng

Department of Cardiac Surgery, UZ Leuven

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Herestraat 49

, 3000 Leuven,

Belgium

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Willem Daenen

Department of Cardiac Surgery, UZ Leuven

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Herestraat 49

, 3000 Leuven,

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Bart Meyns

Department of Cardiac Surgery, UZ Leuven

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Herestraat 49

, 3000 Leuven,

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Peter Verbrugghe

Department of Cardiac Surgery, UZ Leuven

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Herestraat 49

, 3000 Leuven,

Belgium

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Filip Rega

Department of Cardiac Surgery, UZ Leuven

,

Herestraat 49

, 3000 Leuven,

Belgium

Corresponding author. Department of Cardiac Surgery, UZ Leuven, Herestraat 49, 3000 Leuven, Belgium. Tel: +32-16-344260; e-mail: filip.rega@uzleuven.be (F. Rega).

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European Journal of Cardio-Thoracic Surgery, Volume 66, Issue 1, July 2024, ezae267, https://doi.org/10.1093/ejcts/ezae267

Published:

11 July 2024

Article history

Received:

20 March 2024

Revision received:

09 June 2024

Published:

11 July 2024

Corrected and typeset:

27 July 2024

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    Lucas Van Hoof, Bert Rooyackers, Art Schuermans, Jolien Duponselle, Alexander Van De Bruaene, Pieter De Meester, Els Troost, Bart Meuris, Werner Budts, Marc Gewillig, Willem Flameng, Willem Daenen, Bart Meyns, Peter Verbrugghe, Filip Rega, Long-term outcome after the Ross procedure in 173 adults with up to 25 years of follow-up, European Journal of Cardio-Thoracic Surgery, Volume 66, Issue 1, July 2024, ezae267, https://doi.org/10.1093/ejcts/ezae267

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Abstract

OBJECTIVES

The potential risk of autograft dilatation and hom*ograft stenosis after the Ross procedure mandates lifelong follow-up. This retrospective cohort study aimed to determine long-term outcome of the Ross procedure, investigating autograft and hom*ograft failure patterns leading to reintervention.

METHODS

All adults who underwent the Ross procedure between 1991 and 2018 at the University Hospitals Leuven were included, with follow-up data collected retrospectively. Autograft implantation was performed using the full root replacement technique. The primary end-point was long-term survival. Secondary end-points were survival free from any reintervention, autograft or hom*ograft reintervention-free survival, and evolution of autograft diameter, hom*ograft gradient and aortic regurgitation grade over time.

RESULTS

A total of 173 adult patients (66% male) with a median age of 32 years (range 18–58 years) were included. External support at both the annulus and sinotubular junction was used in 38.7% (67/173). Median follow-up duration was 11.1 years (IQR, 6.4–15.9; 2065 patient-years) with 95% follow-up completeness. There was one (0.6%) perioperative death. Kaplan–Meier estimate for 15-year survival was 91.1% and Ross-related reintervention-free survival was 75.7% (autograft: 83.5%, hom*ograft: 85%). Regression analyses demonstrated progressive neoaortic root dilatation (0.56 mm/year) and increase in hom*ograft gradient (0.72 mmHg/year).

CONCLUSIONS

The Ross procedure has the potential to offer excellent long-term survival and reintervention-free survival. These long-term data further confirm that the Ross procedure is a suitable option in young adults with aortic valve disease which should be considered on an individual basis.

Long-term outcome after the Ross procedure in 173 adults with up to 25 years of follow-up (14)

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Ross procedure, Reintervention, Pulmonary autograft, Pulmonary hom*ograft

© The Author(s) 2024. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/pages/standard-publication-reuse-rights)

Subject

Great Vessels Valve Disorders (Acquired Cardiac) Grown-up Congenital Heart Disease Valvular Anomalies (Congenital)

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Long-term outcome after the Ross procedure in 173 adults with up to 25 years of follow-up (2024)

FAQs

What are the long term results of the Ross procedure? ›

The 30-day mortality after the first Ross-related reintervention was 0%, and after all Ross-related reinterventions was 3.8% (n = 1). The 10-year survival rate after reoperation was 96.2% (95% CI, 89.0-100%). The probability of developing higher grades of AR increased over time.

What is the life expectancy after the Ross procedure? ›

One perioperative death occurred. By 25 years, the survival rate for patients who underwent the Ross procedure was 83.0%, nearly matching the 83.7% survival rate seen in the general population (matched for age, country of origin, and sex).

What were the outcomes of the Ross procedure at 20 years? ›

Survival at 20 years was 93.6% and similar to the general population matched for age and sex.

How long is recovery after a Ross procedure? ›

While the Ross procedure is less invasive than other open-heart surgeries, you will still have a hospital stay of approximately four days and restricted activity for up to eight weeks after the operation.

What happens after Ross procedure? ›

Immediately after the operation, you will stay in the intensive care unit (ICU) for one to two days. Then you will move to a recovery room for another three to four days. It takes up to three to four weeks to recover from a Ross procedure. You'll avoid heavy lifting during this period.

What is a complication of Ross procedure? ›

Potential complications with the Ross procedure include[5]: Aortic insufficiency. Right ventricular outlet obstruction. Aortic autograft dilatation.

Can you live 20 years after aortic valve replacement? ›

In the NIHR study, bioprosthetic valves appeared safe, and they were linked to average lifespans when matched to the population having surgery. Ten years after replacement, the great majority of people (94%) had a functioning valve. After 20 years, more valves had failed, with 48% of valves deteriorating.

What are the disadvantages of the Ross procedure? ›

As with any surgery, the Ross procedure may involve certain risks and complications. They include: Bleeding and infection. Stroke, heart attack.

Who is the longest living person with a mechanical heart valve? ›

Seventy-seven-year-old Anne Bell, from Banknock in Falkirk, is the longest surviving recipient of a single artificial heart valve replacement.

How rare is the Ross procedure? ›

However, the Ross procedure accounts for less than 0.1% of all aortic valve replacements performed in the United States (15).

What medications are given after the Ross procedure? ›

Following the Ross procedure, patients may be prescribed medications such as beta blockers to control blood pressure as the pulmonary valve begins its new function as an aortic valve.

How effective is the Ross procedure? ›

“We're able to show that even with the added complexity of surgery that has additional procedures or is a re-operative surgery, outcomes for our Ross patients can still be excellent. Our survival rate is 100 percent, and the risk of reoperation for either the aortic or the conduit pulmonary valve is very low.”

What is the life expectancy after mitral valve repair? ›

Almost as many (90%) can go 20 years. Most people don't need another mitral valve surgery after a successful repair. You'll need an echocardiogram each year so your provider can check on your valve function. You may also need antibiotics before certain procedures to prevent endocarditis (an infection of your valve).

Can losing weight help a leaky heart valve? ›

Many heart-healthy lifestyle changes can help reduce the symptoms of heart valve disease, and in some cases, may even prevent the progression of certain symptoms. Eating a heart- healthy diet, aiming for a healthy weight, engaging in regular physical exercise, and managing your stress can help.

What is the success rate of the Ross Konno procedure? ›

There were 8 (5%) early deaths, 6 of whom underwent the Ross-Konno procedure, and 10 (7%) late deaths. Survival rates at 15 and 20 years were 86% in the total cohort and 91% in the isolated Ross subgroup.

What are the long term outcomes after surgical repair of complete atrioventricular septal defect? ›

The estimated freedom from reoperation was 88% at 10 years, 83% at 20 years, and 78% at 30 years after initial CAVSD repair. Indications for reoperation included left atrioventricular valve regurgitation in 14 patients (7.1%) and left ventricular outflow obstruction in 7 patients (3.5%).

What is the success rate of the Ross-Konno procedure? ›

There were 8 (5%) early deaths, 6 of whom underwent the Ross-Konno procedure, and 10 (7%) late deaths. Survival rates at 15 and 20 years were 86% in the total cohort and 91% in the isolated Ross subgroup.

What are the long term outcomes following the surgical repair of traumatic Cyclodialysis clefts? ›

Successful cyclodialysis cleft repair can lead to a good long-term visual prognosis and stable IOP control, even in cases with a protracted history of ocular hypotony.

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